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• 
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• Principal Investigators
  • Nakatatsuji, Norio
  • Kitagawa, Susumu
  • Agladze, Konstantin
  • Chen, Yong
  • Harada, Yoshie
  • Hashida, Mitsuru
  • Heuser, John
  • Hiiragi, Takashi
  • Imahori, Hiroshi
  • Kengaku, Mineko
  • Kiso, Makoto
  • Kusumi, Akihiro
  • Sugiyama, Hiroshi
  • Takano, Mikio
  • Tanaka, Koichiro
  • Ueda, Kazumitsu
  • Uesugi, Motonari
  • Yamanaka, Shinya
• Satellite Labs,
  Research Innovation and Communication
  • Suzuki, Kenichi (NCBS-inStem Satellite Lab)
  • Sengoku, Shintaro (Innovation Management)
  • Kato, Kazuto (Science Communication)
• iCeMS Kyoto Fellows
  • Carlton, Peter
  • Kalay, Ziya
  • Kim, Franklin
  • Murakami, Tatsuya
  • Yamamoto, Takuya
• Adjunct Professors
  • Hayashi, Tamio
  • Shinohara, Takashi
  • Kitagawa, Hiroshi
  • Kageyama, Hiroshi
  • Saitou, Mitinori
  • Shirakawa, Masahiro
  • Kotera, Hidetoshi
  • Kageyama, Ryoichiro
  • Matsuda, Michiyuki
  • Shinkai, Yoichi
  • Akiyoshi, Kazunari
  • Hamachi, Itaru
  • Mori, Yasuo
• Staff Directory
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Yamanaka, Shinya
Stem Cell Biology, Developmental Engineering

Member

Yamanaka, Shinya	Professor / Director of the Center for iPS Cell Research and Application (CiRA)
Yamada, Yasuhiro	Professor
Yoshida, Yoshinori	Senior Lecturer
Hotta, Akitsu	Assistant Professor
Watanabe, Akira	Assistant Professor
Woltjen, Knut	Assistant Professor
Panula, Sarita P.	Research Associate
Fujimoto, Naoko	Research Associate

Research Overview

Our research group is focused on stem cell biology and developmental engineering. In particular, we have established mouse and human induced pluripotent stem cells (iPS cells), and we are carrying out various aspects of basic and applied research using iPS cell technology.

iPS cells can be generated from a wide range of somatic cell types, and many different methods have been developed for their generation. It is believed, however, that iPS cells are not in fact completely identical with ES cells. Using cell biology methods, including in vitro differentiation induction, and molecular biology methods, we plan to evaluate the pluripotency and safety of these cell types. By expanding our understanding of the mechanisms that underlie reprogramming and pluripotency, we aim to generate and culture iPS cells compatible for use in clinical applications. We also seek to use patient-specific iPS cells to study disease mechanisms and applications in drug development.

Using the viral vector transgene delivery system which drives the undifferentiated pluripotent stem cell-specific expression of GFP and drug-resistance genes as a high-efficiency method of selecting human iPS cells, we have facilitated the derivation of various patient-specific iPS cell lines and investigated the intra-nuclear changes that accompany the reprogramming process. With this platform, we will develop techniques for the generation and selection of safer human iPS cells, aiming for a novel iPS-based gene therapy approach to the treatment of hemophilia and other genetic disorders.

We are also working to change the epigenetic status in cancer cells using reprogramming technology, thereby making differences between genetic abnormality and epigenetic status in cancer cells. Through the analysis of the biological behaviors of these reprogrammed cancer cells, we seek the significance of epigenetic abnormality in carcinogenesis. Our goal is to find out the original epigenetic abnormality which causes the cancer through an analysis of epigenetic changes in the reprogrammed cancer cells and to develop a new "epigenetic cancer therapy" which resets the epigenetic state in cancer cells.

	Yamanaka Lab Research Overview

	Movie: Beating cardiomyocytes grown from differentiated mouse iPS cells

Contact

Email	yamanaka-g@icems.kyoto-u.ac.jp
Phone	+81-75-751-4983
Website	Yamanaka Lab Center for iPS Cell Research and Application (CiRA)