[Cancelled] 74th iCeMS Seminar: Prof. Dr. Lutz Schmitt

We very much regret to announce that this seminar has been cancelled.

Multidrug resistance can be a major challenge in the therapy of cancer and pathogenic fungal infections. More than three decades ago, P-glycoprotein was the first multidrug transporter identified, and P-gp has been extensively studied at the genetic and biochemical levels ever since. Pdr5, the most abundant ABC transporter in Saccharomyces cerevisiae, is highly homologous to azole-resistance-mediating multidrug transporters in fungal pathogens, and a focus of clinical drug resistance research. Despite functional equivalences, P-gp and Pdr5 exhibit striking differences in their architecture. Here, I will summarize our recent results of mutations that affect substrate selection and transport. These results will be summarized in a model that takes kinetic selection principles into account.

Lecturer Title	Prof. Dr. Lutz Schmitt Institute of Biochemistry Heinrich Heine University Düsseldorf Title: Pdr5 — an ABC transporter for all seasons?
Date / Time	March 24, 2011 / 16:30-17:30 Cancelled
Venue	2nd floor Seminar Room (#A207), Main Building iCeMS Complex 1, Kyoto University Directions
Flyer	PDF (384KB)
Host	Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
Contact	iCeMS Ueda Lab ueda-g@icems.kyoto-u.ac.jp