150th iCeMS Seminar: Prof. Zhu-Jun Yao
Annonaceous acetogenins have been attracting worldwide attention as potent inhibitors against proliferation of various tumor cells and environmental neurotoxins for more than 30 years. Mechanism studies mentioned that this large family of plant polyketides might target Complex I of mitochondria during their actions. Our 10-year-long studies on bullatacin, a typical cytotoxic natural annonaceous acetogenin, and corresponding natural product-like mimicking have discovered a number of simplified compounds exhibiting potent antitumor activity and significant action selectivity between human normal and cancerous cells. Furthermore, a representative mimic AA005 has been successfully developed and applied as a molecular tool to explore the unique mechanism of selective anticancer action.
| Lecturer |  Nanjing University School of Chemistry and Chemical Engineering |
|---|---|
| Title | Natural Product-like Mimicry of Annonaceous Acetogenins |
| Date / Time | Fri, 29 Nov 2013 / 11:00-11:40 |
| Venue | CB-217 Lecture Room 3 Institute for Chemical Research Uji Research Bldg (#19), Kyoto University -> Directions |
| Flyer |  PDF (100KB) |
| Host | Kyoto University Institute for Integrated Cell-Material Sciences (WPI-iCeMS) | Contact | iCeMS Uesugi Lab | uesugi-g@icems.kyoto-u.ac.jp |