197th iCeMS Seminar: Dr. Yuichiro Takagi
Mediator is an essential regulator of eukaryotic transcription. It is a gigantic multi-protein complex composed of 21 subunits with a molecular mass exceeding 1 Mega daltons.
The structural complexity of Mediator has been a huge roadblock for structure-function studies on Mediator. We have developed a new technology, which enables us to reconstitute the 21-subunit full Mediator complex, opening new avenues to understand how Mediator functions during transcription, and why mutations disrupt its function, leading toward determining the transcription activation mechanisms by Mediator.
| Lecturer |  Department of Biochemistry and Molecular Biology Indiana University School of Medicine, US |
|---|---|
| Title | Synthetic biology approach to uncover structure and function of the Mediator of transcription regulation |
| Date / Time | Mon, 28 Dec 2015 / 15:30-16:30 |
| Venue | 2nd Floor Seminar Room (#A207), iCeMS Main Building (#77), Kyoto University -> Directions |
| Flyer |  PDF (139KB) |
| Host | Kyoto University Institute for Integrated Cell-Material Sciences (iCeMS) | Contact | iCeMS Harada Lab | harada-g@icems.kyoto-u.ac.jp |