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Research Interest

Chemical Biology, DNA-based smart biomaterial design
My research goal is to harness chemical biology of nucleic acids and create smart biomimetic materials with versatile applications. We develop synthetic genetic switches closely mimicking natural cell control factors that may precisely control the instruction program of human cells and reprogram them for clinical use. We use the programmable feature of DNA to construct biomimetic multidimensional nanostructures, functional nanosystems and biodevices to monitor and modulate the working principle inside the living systems.

What I like about my science

I like my science because it allows me to be free from getting restricted within particular disciplinary barriers that limit creative capacity. Also, a multi-disciplinary perspective at precise coordination existing between the natural biomolecules empowers me to construct innovative biomaterials.

Researcher Q & A

Where are you from?

Shizuoka-shi, Shizuoka

Why did you become a researcher?

Being a researcher fascinates me as I can make my own unique contribution for the benefit of humankind. Also, my thoughts get a virtual and valuable identity.

What is your favorite experiment, theory, device, reagent, lab equipment? Why do you like it?

I like Koopmans’ theorem that showed that the calculation of a molecule’s ionization potential through the energy of the highest occupied molecular orbital. Interestingly, this concept is useful in diverse disciplines and hence, fetched a Nobel Prize for Tjalling Koopmans in Economics!! My favorite lab equipment is the Next Generation Sequencer because it gives us amazing high resolution and valuable information about protein-DNA interactions and genome-wide DNA structural changes.

What is your hobby?

I like the gentle outward appearance of Tom Hanks, and his movies such as You’ve Got Mail, Big, and Splash are my favorites. I have visited the locations of these movies in New York and Seattle.

My hobby is to go sightseeing ancient Chinese cities feeling like a Japanese envoy to Sui Dynasty China.

This image shows SAHA-PIP conjugates binding to specific DNA arrays, which inhibits HDAC and induces acetylation of histones by HAT in the surrounding areas.