第17回 アイセムスセミナー：Dietrich Keppler 教授

Transport proteins mediating the uptake and efflux of small molecules across cellular membrane domains are key determinants of the absorption, disposition, and elimination of many drugs and endogenous substances. Cell lines stably expressing uptake and/or efflux transporters demonstrate the decisive role of transport proteins in the vectorial transport of many organic anions, organic cations, and neutral compounds across polarized epithelial cells. In vitro systems for studies on vectorial transport of the cationic berberine include double-transfected polarized cells permanently expressing the human organic cation transporter 1 (OCT1, SLC22A1) together with the efflux pump MDR1 P glycoprotein (ABCB1). Cells stably expressing OATP1B3 as uptake transporter together with the efflux pump MRP2 (ABCC2) served in the data-based mathematical modeling of vectorial transport of the anionic bromosulfophthalein and resulted in a quantitative description of this process and its components.

講演者	Prof. Dr. Dietrich Keppler German Cancer Research Center
演題	Vectorial Transport of Small Molecules Across Cellular Membranes by Uptake and Efflux Transport Proteins
日時	2009年3月19日（木曜日） 15時30分-16時30分
場所	iCeMSコンプレックス1 西館 2階会議室 アクセスマップ
フライヤー	PDF (743 KB)
主催	京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス）
連絡先	植田グループ　ueda-g@icems.kyoto-u.ac.jp