第39回 アイセムスセミナー: Dr. Thomas Biederer
Synapse formation is required to wire neuronal circuits in the developing brain, and remodels adult circuits during learning. Our group investigates the roles of cell adhesion in guiding synaptogenesis. We focus on the roles of SynCAM proteins, synaptogenic adhesion molecules of the immunoglobulin superfamily. This seminar will present recent results that SynCAM 1 participates in the first steps of axo-dendritic contact interaction, and then remains at synapses to guide their development. At developing synapses, SynCAM proteins form trans-synaptic adhesion complexes that drive excitatory synapse formation. SynCAM 1 is then required to maintain this increase in synapses. Further, SynCAM adhesion acts at mature synapses to regulate their ability to undergo activity-dependent changes in synaptic strength. Together, our studies utilize biochemistry, live imaging, physiological studies, and mouse models to analyze the molecular interactions that organize synapses.
| 講演者 | Dr.Thomas Biederer Department of Molecular Biophysics and Biochemistry Yale University |
|---|---|
| 演題 | Synapse Organization by Trans-Synaptic SynCAM Complexes |
| 日時 | 2009年11月30日（月）10:30-11:30 |
| 場所 | 京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207) アクセスマップ |
| フライヤー |  PDF (360KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 連絡先 | 京都大学iCeMS見学グループ kengaku-g@icems.kyoto-u.ac.jp |