第68回 アイセムスセミナー / CeMI セミナーシリーズ 20: István Ábrahám博士、György Vereb准教授
CeMI：Center for Meso-Bio Single-Molecule Imaging
Non-classical action of estrogen in the brain: from neurons to single molecules
(Dr. István Ábrahám)
Estrogen secreted from the ovary alters the function of several neuronal phenotypes. Cholinergic neurons degenerate in Alzheimer's disease and estrogen plays a role in determining the vulnerability of cholinergic neurons in this condition. The estrogen also acts a feedback manner to alter the function of gonadotropin releasing hormone (GnRH) neurons, the central "processor unit" of the fertility. Although estrogen primarily alters the neuronal activity by modulating gene expression directly it also exerts "non-classical" effects on neurons by altering signal transduction pathways. Using immunohistochemistry, transgenic technology, calcium imaging, single cell electrophysiology and single molecule detection, we demonstrate the mechanism and role of estrogen-induced "non-classical" effect on signalling molecules in cholinergic and GnRH neurons.
ErbB receptor tyrosine kinase interactions: from the microscopic data to clinical relevance
(Assoc. Prof. György Vereb)
Deregulated proliferation leading to tumors is often based on signaling by receptor tyrosine kinases including those of the ErbB (EGFR) family. Quantitative microscopic techniques including FRET and fluctuation spectroscopy (FCS) have offered the possibility to learn about molecular interactions of ErbB1 and ErbB2 with each other, integrins, and other ECM constituents that explain membrane organization of these entities, some aspects of their (trans)activation, and possible roles in the therapy resistance of various tumors, as well as provide clues for alternative therapeutic and predictive diagnostic approaches.
| 講演者 演題 |
Dr. István Ábrahám Centre for Neuroendocrinology & Department of Physiology ニュージーランド University of Otago 演題：Non-classical action of estrogen in the brain: from neurons to single molecules Assoc. Prof. György Vereb Department of Biophysics and Cell Biology Medical and Health Science Center, Faculty of Medicine ハンガリー University of Debrecen 演題：ErbB receptor tyrosine kinase interactions: from the microscopic data to clinical relevance |
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| 日時 | 2011年3月2日（水）11:30-12:50 |
| 場所 | 京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207) アクセスマップ |
| フライヤー |  PDF (136KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 連絡先 | iCeMS 楠見明弘 / Fax: 075-751-4113 akusumi@frontier.kyoto-u.ac.jp |