第69回 アイセムスセミナー: Christine Métin 博士
The first steps of the cortical development are characterized by long distance cellular movements associated to spectacular morphological changes of the futur cortical neurons. Inhibitory cortical interneurons are born outside the cortex in the basal telencephalon and reach the developing cortical plate after a long, so-called tangential migration. We have developed co-culture models to analyse the cycle of migration of the future cortical interneurons using time-lapse videomicroscopy. These neurons present a two-step nucleokinesis correlated to the production of branches at the leading edge. Nuclear translocations are preceded by a long, forward movement of the endoplasmic reticulum and Golgi apparatus. Forces developed at the rear by the acto-myosin system participate in pushing the nucleus forward. Time-lapse recordings show that the centrosome most often positions at nuclear front although it can maintain at nuclear rear during the migration. Our functional data suggest that the centrosome controls cell shape and motility through an original mechanism.
| 講演者 | Christine Métin 博士 Institut du Fer à Moulin, Inserm |
|---|---|
| 演題 | A new function of the centrosome in migrating cortical interneurons |
| 日時 | 2011年3月9日（水）11:00-12:00 |
| 場所 | 京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207) アクセスマップ |
| フライヤー |  PDF (356KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 連絡先 | iCeMS 見学グループ kengaku-g@icems.kyoto-u.ac.jp |