【中止】第74回 アイセムスセミナー: Prof. Dr. Lutz Schmitt
大変申し訳ございませんが、当セミナーは中止になりました。
Multidrug resistance can be a major challenge in the therapy of cancer and pathogenic fungal infections. More than three decades ago, P-glycoprotein was the first multidrug transporter identified, and P-gp has been extensively studied at the genetic and biochemical levels ever since. Pdr5, the most abundant ABC transporter in Saccharomyces cerevisiae, is highly homologous to azole-resistance-mediating multidrug transporters in fungal pathogens, and a focus of clinical drug resistance research. Despite functional equivalences, P-gp and Pdr5 exhibit striking differences in their architecture. Here, I will summarize our recent results of mutations that affect substrate selection and transport. These results will be summarized in a model that takes kinetic selection principles into account.
| 講演者 演題 |
Prof. Dr. Lutz Schmitt Institute of Biochemistry ドイツ デュッセルドルフ大学 演題：Pdr5 — an ABC transporter for all seasons? |
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| 日時 | |
| 場所 | 京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207) アクセスマップ |
| フライヤー |  PDF (412KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 連絡先 | iCeMS 植田グループ ueda-g@icems.kyoto-u.ac.jp |