第75回 アイセムスセミナー: 末次 志郎 准教授
The plasma membrane, the outermost surface of eukaryotic cells, contains various mesoscale substructures of invaginations and protrusions, which are associated with endocytosis and cell migration. The diverse members of the BAR domain superfamily proteins have structurally determined positive and negative curvatures of membrane contact at their BAR, F-BAR, and I-BAR domains, which are thought to generate and maintain such curved membranes by binding to the membrane of various subcellular structures. Importantly, the SH3 domains of the BAR domain superfamily proteins bind to the actin regulatory WASP/WAVE proteins, thereby connecting WASP/WAVE proteins to specific membrane curvatures of each subcellular structure. At least these connections were found in endocytosis of clathrin-coated pits and caveolae as well as protrusive structures such as filopodia and lamellipodia. The orientation and extent of filament growth to the membrane could be regulated by these connections specific for each subcellular structure. Furthermore, these BAR domain-mediated protein assembly could regulate signal transduction for cancer cell proliferation and invasion.
| 講演者 | 末次 志郎 准教授 東京大学 分子細胞生物学研究所 細胞形態研究分野 |
|---|---|
| 演題 | Molecular assemblies of mesoscale membrane structures involved in cancer |
| 日時 | 2011年4月13日（水）10:00-11:00 |
| 場所 | 京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207) アクセスマップ |
| フライヤー |  PDF (380KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 連絡先 | iCeMS イノベーションマネジメントグループ sengoku-g@icems.kyoto-u.ac.jp |