第85回 アイセムスセミナー: Prof. Dr. Jan Reedijk

Metal compounds known to have an effect on health, usually have a negative effect, and this has contributed to the general opinion that metals are dangerous and have to be avoided. Such metal compounds can also be useful in important Medicinal Applications, as will be illustrated in the lecture.

The lecture will also deal with the applications of metal compounds in the treatment of cancer. A strong focus will be given on the mechanism of action related to cisplatin-DNA binding, and the use of this mechanistic knowledge to develop new, improved metal-containing drugs.

Metal coordination compounds of Pt and Ru have metal-ligand exchange rates comparable to cell-division processes. This may explain that often they are highly active as anticancer agents (1,2). Multifunctional DNA binding of such compounds allows the use of a fluorescent group to follow the process of the compounds online, while being processed in the cells. Combination of Cu-DNA binding with platinum has resulted in new compounds, to be used for both DNA cutting and for new anticancer chemistry approaches.

(1) J. Reedijk; Plat. Metals Rev., 52, (2008), 2-11
(2) J. Reedijk; EURJIC, (2009), 1303-12.

講演者 Prof. Dr. Jan Reedijk
Leiden Institute of Chemistry
オランダ ライデン大学
演題 Heavy Metals as Useful Drugs
日時 2011年9月5日(月)15:00-16:30
場所 京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207)
アクセスマップ
フライヤー PDF FilePDF (143KB)
主催 京都大学 物質-細胞統合システム拠点(iCeMS=アイセムス)
共催 京都大学医学研究科グローバルCOEプログラム「生命原理の解明を基とする医学研究教育拠点」
連絡先 iCeMS 北川グループ
kitagawa-g@icems.kyoto-u.ac.jp