第95回 アイセムスセミナー: Prof. Guangxiu Lu, Assoc. Prof. Ge Lin

Prof. Guangxiu Lu

Modelling Glanzmann thrombasthenia with human induced pluripotent stem cells

Glanzmann thrombasthenia (GT) is a rare autosomal recessive genetic hemorrhagic disorder resulting from deficiency or functional defect of platelet receptor glycoprotein (GP) IIb/IIIa (GPIIb is also known as CD41). In this study, we characterized the genotype of a GT patient and then generated induced pluripotent stem cells (iPSCs) from the patient's fibroblast. GT-iPSCs have the same characteristics as embryonic stem cells (ESCs) and can be differentiated to yolk-sac-like structures. Platelets derived from GT Yolk-sac-like structures (GT-iPS-platelet) are defective in platelet function. Furthermore, expression of normal CD41 in GT-iPS platelets restored platelet function. Our study suggested that iPSCs could be used to generate GT model and to be a target of GT gene therapy.

Assoc. Prof. Ge Lin

Stem cell activities in National Engineering and Research Center of Human Stem Cells

This is a brief overview of the history and major stem cell projects nowadays implemented in National Engineering and Research Center of human stem cells. Both research activities on human embryonic stem cell and adult stem cell will be addressed.

講演者	Prof. Guangxiu Lu Assoc. Prof. Ge Lin 中国 中南大学 Institute of Reproduction and Stem Cell Engineering Reproductive & Genetic Hospital CITIC-Xiangya National Engineering Research Center of Human Stem Cells
日時	2011年11月25日（金）17:00-18:30
場所	京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207) アクセスマップ
フライヤー	PDF (110KB)
主催	京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス）
共催	京都大学医学研究科グローバルCOEプログラム「生命原理の解明を基とする医学研究教育拠点」
連絡先	iCeMS イノベーションマネジメントグループ sengoku-g@icems.kyoto-u.ac.jp