第100回 アイセムスセミナー: 中山 功一 教授
Fabrication of transplantable 3D tissues or organs in vitro is one of the major goals in regenerative medicine. Several scaffold-free systems have been developed to avoid potential side effects caused by scaffold mainly used to build three-dimensional tissue constructs. However, they seemed to be still unable to produce fine structures without contamination from exogenous biochemical materials. Inspired from bone fracture treatments in orthopedic surgery, we have established a simple method to fabricate 3D scaffold-free cell constructs. This method uses spheroids and temporal fixators which enable placement of various types of three-dimensional cells into desired xyz positions without need of hydrogels or biochemical reactive materials.
We also developed a robotic system for scaffold-free cell construction. The prototype can handle two different types of cells and fabricate 10 mm3 scaffold-free cell constructs. We consider that the simplicity and scalability of this unique system will facilitate its clinical introduction. Near future, with combination of the robotic technology and the biotechnology, we may be able to build living organs for autologous transplantation. And this multi-cell construct may be a useful research tool for drug development.
| 講演者 演題 |
中山 功一 教授 佐賀大学 大学院工学系研究科 先端融合工学専攻 演題：A New Approach for 3D Tissue & Organ Fabrication Inspired From Orthopedic Surgery |
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| 日時 | 2012年1月17日（火）17:00-18:00 |
| 場所 | 京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207) アクセスマップ |
| フライヤー |  PDF (109KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 共催 | 京都大学医学研究科グローバルCOEプログラム「生命原理の解明を基とする医学研究教育拠点」 |
| 連絡先 | iCeMS イノベーションマネジメントグループ（IMG） sengoku-g@icems.kyoto-u.ac.jp |