第112回 アイセムスセミナー: Prof. Chia-Chun Chen

The controlled growth of Au and FePt nanoparticles has been performed. In particular, the water-solvable FePt nanoparticles with different diameters were applied as a dual modality contrast agent for CT/MRI molecular imaging. Anti-Her2 antibody conjugated FePt nanoparticles demonstrated molecular expression dependent CT/MRI dual imaging contrast effect in MBT2 cell line and its Her-2/neu gene knock out counterpart. Selective contrast enhancement of Her2/neu overexpression cancer lesions in both CT and MRI was found in tumor bearing animal after tail vein injection of FePt nanoparticle. Furthermore, the potentials using FePt nanoparticles for cancer therapeutics under radiative irradiation will be also discussed here. Besides FePt nanoparticles, gold nanorods conjugated with DNA or anti-cancer drug have been prepared. The conjugates of DNA (or drug) and gold nanorods were developed to investigate gene (or drug) delivering capability in cellular systems. By using near IR irradiation, we are able to remotely and locally activate the DNA expression after the conjugates entered the cells. The advantages of using nanomaterials for the drug delivery applications will be also discussed.

講演者 演題	Prof. Chia-Chun Chen Department of Chemistry 国立台湾師範大学 Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan 演題：Applications of Metal Nanoparticles for Biomolecule Delivery and CT/MR Molecular Imaging
日時	2012年6月25日（月）15:00-16:00
場所	京都大学 iCeMS 本館（#71）2階 セミナールーム (A207) アクセスマップ
フライヤー	PDF (113KB)
主催	京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス）
共催	京都大学医学研究科グローバルCOEプログラム「生命原理の解明を基とする医学研究教育拠点」
連絡先	iCeMS 髙野グループ takano-g@icems.kyoto-u.ac.jp