第117回 アイセムスセミナー: 笹井 理生 教授
Construction of the sound theoretical framework of gene expression has been strongly desired to quantitatively understand processes in eukaryotic cells. In this seminar, I will explain our recent efforts toward this goal. We first discuss the stochastic dynamics of the core-gene network of mouse embryonic stem (ES) cells. Phenotypic heterogeneity of cultured population of ES cells is explained by the slow switching dynamics of Nanog expression. With this slow switching, dynamics of the gene network is regarded as a sequence of transitions among transient cell states. Effects of the slow switching dynamics on the pathway of transitions and on the cell-fate decision are discussed by using the calculated epigenetic landscapes. A possible mechanism of the slow switching dynamics of gene expression is the dynamical change of chromosome organization. By using the haploid budding yeast cell as an example, we explain the molecular dynamics simulation of chromosomes to understand the correlation between the chromosome structures and the gene expression patterns. We discuss fluctuations of the genome around the averaged structure inferred from the 3C data.
| 講演者 演題 |
笹井 理生 教授 名古屋大学 大学院 工学研究科 計算理工学専攻 演題：Fluctuations in epigenetic switches and landscapes |
|---|---|
| 日時 | 2012年9月12日（水）10:00-11:00 |
| 場所 | 京都大学 iCeMS 本館（#71）2階 セミナールーム (A207) アクセスマップ |
| フライヤー |  PDF (218KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 共催 | 京都大学医学研究科グローバルCOEプログラム「生命原理の解明を基とする医学研究教育拠点」 |
| 連絡先 | iCeMS Kalayグループ kalay-g@icems.kyoto-u.ac.jp |