第126回 アイセムスセミナー: 柴 祐司 博士
Transplantation studies in mice and rats have provided exciting proof-of-concept for the use of hESC-derived cardiomyocytes (hESC-CMs) in cardiac repair, but two critical issues related to their electrophysiological behavior in vivo remain unresolved. First, it has not be determined whether hESC-CMs are capable of undergoing hESC-CMs appropriate electromechanical integration following transplantation in injured hearts, as would be necessary for them to provide new force generating units during systole. A second, related uncertainty is whether their transplantation will increase or decrease the incidence of arrhythmias. Here we use a novel guinea pig model to show that hESC-CM grafts can indeed couple with host muscle in both intact and injured hearts and that their transplantation substantially enhances the electrical stability of injured hearts.
| 講演者 |  信州大学大学院 医学系研究科 循環器病病態学 助教 |
|---|---|
| 演題 | Human ESC-Derived Cardiomyocytes Integrate and Suppress Arrhythmias in a Guinea Pig Infarct Model |
| 日時 | 2012年11月26日（月）17:00-18:00 |
| 場所 | 京都大学 iCeMS 西館 2階 セミナールーム →アクセスマップ |
| フライヤー |  PDF (90KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 共催 | 京都大学医学研究科グローバルCOEプログラム「生命原理の解明を基とする医学研究教育拠点」 |
| 連絡先 | iCeMS 国際企画セクション rp@icems.kyoto-u.ac.jp |