第145回 アイセムスセミナー: Peng Yin 助教

I will discuss my lab's research on engineering synthetic, nucleic acidbased nanostructures and applications. We have recently invented a general framework for programming the self-assembly of short synthetic nucleic acid strands into prescribed target shapes or demonstrating their prescribed dynamic behavior. Using short DNA strands, we have demonstrated the modular construction of sophisticated 2D and 3D structures on the 100-nanometer scale with nanometer precision. Using reconfigurable DNA hairpins, we have demonstrated diverse, dynamic behavior such as catalytic circuits, triggered assembly, and autonomous locomotion. By interfacing these synthetic, nucleic acid nanostructures with functional molecules, we are developing a diverse range of applications. In biosensing, we have constructed robust and specific probes for detecting single-base changes in a single-stranded DNA/RNA target. In bioimaging, we have engineered geometrically encoded fluorescent barcodes for highly multiplexed single-molecule imaging. In nanofabrication, we have developed a versatile framework for producing inorganic materials (e.g. graphene, silicon dioxide, silver, gold) with arbitrarily prescribed nanometer scale shapes. Finally, I'll discuss our ongoing work to move the nanostructures from test tubes to living cells.

講演者
Peng Yin 助教
米ハーバード大学医学大学院 システム生物学部門
演題 Programming Nucleic Acids Self-Assembly
日時 2013年10月29日(火)15:00-17:05
場所 京都大学 iCeMS 本館(#70)2階 セミナールーム (A207)
アクセスマップ
フライヤー PDF FilePDF (100KB)
主催 京都大学 物質-細胞統合システム拠点(iCeMS=アイセムス)
連絡先 iCeMS 杉山グループ | sugiyama-g@icems.kyoto-u.ac.jp