第159回 アイセムスセミナー: KiBum Lee 准教授

This presentation will focus on the interface between nanomedicine and stem cell biology. Even though it is well-established that stem cell fate is regulated by interactions that occur between microenvironmental cues and intrinsic cellular programs, our understanding of the function of the microenvironment and gene expression in neural stem cells is hampered by the limitations of conventional methods and the lack of extensive knowledge of multiple regulatory signals. If complex stem cell behaviors, such as dierentiation and proliferation, are to be fully investigated, both approaches from nanotechnology--the "top-down" patterning of extracellular matrix (ECM) and signal molecules (e.g. ECM compositions, nanotopography, pattern geometry, and pattern density), and the "bottom-up" synthesis of multifunctional nanoparticles and their surface modication with specic signal molecules--should be combined synergistically. To address the aforementioned challenges, our research mainly focuses on two approaches: i) the development of combinatorial arrays of microenvironmental signal molecules for the investigation of stem cell behaviors; and ii) the synthesis and utilization of multifunctional nanoparticles as drug (e.g. small molecules or siRNA) and gene delivery vehicles to manipulate the expression of key genes in stem cells.

More specically, we have applied combinatorial signal arrays to study the temporal/spatial eect of microenvironmental cues on adhesion, growth, and dierentiation of neural stem cells. Furthermore, novel multifunctional nanosystems such as magnetic coreshell nanoparticles and graphene-hybrid nanomaterials were developed and utilized to deliver genetic materials into stem cells for controlling their neural-differentiation pathways and neuronal behaviors (Figure 1.). In this presentation, a summary of the most updated results from these eorts and future directions will be discussed.

講演者
KiBum Lee 准教授
Department of Chemistry and Chemical Biology
Rutgers University
演題 Nanotechnology approaches for controlling neural stem cell fate
日時 2014年2月27日(木)15:00-16:00
場所

京都大学 iCeMS 本館(#70)2階 セミナールーム (A207)
アクセスマップ

フライヤー PDF FilePDF (324KB)
主催 京都大学 物質-細胞統合システム拠点(iCeMS=アイセムス)
連絡先 Chen グループ | chen-g@icems.kyoto-u.ac.jp