58th iCeMS Seminar: Asst. Prof. Clifton Kwang-Fu Shen

The microscale radiolabeling of biologics using a versatile 18F-tag was demonstrated in our digital microfluidic chips. Consuming only small amounts of samples, the optimal conjugation parameters were obtained rapidly by screening individual droplets with different compositions. Batches of products can be then generated from one single droplet to a mouse-dose scale for probe evaluation or/and in vivo studies. Our idea is to create a device capable of preparing various biologics-based, target-specific PET probes on demand, in an automated fashion with minimal operator skill. Our vision is to make PET probes easily accessible so that researchers can study the underlying biology of diseases and, at the same time, clinicians can gather more detailed molecular information about each individual patient before choosing therapeutics and monitor progress after the targeted treatments.

Lecturer	Asst. Prof. Clifton Kwang-Fu Shen Director of Crump Cyclotron Facility and Radiochemistry Technology Center, Crump Institute for Molecular Imaging Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA
Title	PET Probe Development Using Digital Microfluidics
Date / Time	September 10, 2010 / 16:00-17:00
Venue	2nd floor Seminar Room (#A207), Main Building iCeMS Complex 1, Kyoto University Directions
Flyer	PDF (108KB)
Host	Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
Contact	iCeMS Asst. Prof. Ken-ichiro Kamei chen-g@icems.kyoto-u.ac.jp