95th iCeMS Seminar: Prof. Guangxiu Lu, Assoc. Prof. Ge Lin

Prof. Guangxiu Lu

Modelling Glanzmann thrombasthenia with human induced pluripotent stem cells

Glanzmann thrombasthenia (GT) is a rare autosomal recessive genetic hemorrhagic disorder resulting from deficiency or functional defect of platelet receptor glycoprotein (GP) IIb/IIIa (GPIIb is also known as CD41). In this study, we characterized the genotype of a GT patient and then generated induced pluripotent stem cells (iPSCs) from the patient's fibroblast. GT-iPSCs have the same characteristics as embryonic stem cells (ESCs) and can be differentiated to yolk-sac-like structures. Platelets derived from GT Yolk-sac-like structures (GT-iPS-platelet) are defective in platelet function. Furthermore, expression of normal CD41 in GT-iPS platelets restored platelet function. Our study suggested that iPSCs could be used to generate GT model and to be a target of GT gene therapy.

Assoc. Prof. Ge Lin

Stem cell activities in National Engineering and Research Center of Human Stem Cells

This is a brief overview of the history and major stem cell projects nowadays implemented in National Engineering and Research Center of human stem cells. Both research activities on human embryonic stem cell and adult stem cell will be addressed.

Lecturer Prof. Guangxiu Lu
Assoc. Prof. Ge Lin
Institute of Reproduction and Stem Cell Engineering,
Central South University, China
Reproductive & Genetic Hospital CITIC-Xiangya
National Engineering Research Center of Human Stem Cells
Date / Time November 25, 2011 / 17:00-18:30
Venue 2nd floor Seminar Room (#A207), Main Building
iCeMS Complex 1, Kyoto University
Directions
Flyer PDF FilePDF (110KB)
Host Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
Co-Host Center for Frontier Medicine, Global COE Program, Kyoto University
Contact iCeMS Innovation Management Group (IMG)
sengoku-g@icems.kyoto-u.ac.jp