126th iCeMS Seminar: Dr. Yuji Shiba
Transplantation studies in mice and rats have provided exciting proof-of-concept for the use of hESC-derived cardiomyocytes (hESC-CMs) in cardiac repair, but two critical issues related to their electrophysiological behavior in vivo remain unresolved. First, it has not be determined whether hESC-CMs are capable of undergoing hESC-CMs appropriate electromechanical integration following transplantation in injured hearts, as would be necessary for them to provide new force generating units during systole. A second, related uncertainty is whether their transplantation will increase or decrease the incidence of arrhythmias. Here we use a novel guinea pig model to show that hESC-CM grafts can indeed couple with host muscle in both intact and injured hearts and that their transplantation substantially enhances the electrical stability of injured hearts.
| Lecturer |  Assistant Professor Department of Cardiovascular Medicine, Shinshu University |
|---|---|
| Title | Human ESC-Derived Cardiomyocytes Integrate and Suppress Arrhythmias in a Guinea Pig Infarct Model |
| Date / Time | Monday, November 26, 2012 / 17:00-18:00 |
| Venue | 2nd floor Seminar Room, iCeMS West Building, Kyoto University -> Directions |
| Flyer |  PDF (90KB) |
| Host | Kyoto University Institute for Integrated Cell-Material Sciences (WPI-iCeMS) |
| Co-host | Kyoto University's Global COE Program: Center for Frontier Medicine |
| Contact | iCeMS Reserach Planning Section rp@icems.kyoto-u.ac.jp |