158th iCeMS Seminar: Assoc Prof Laszlo Kohidai
Chemotaxis is one of the most signicant cellular responses in functional cell biology. Integrated
cellular, biomaterial and functional complexity of the response system (cell adhesion - chemotaxis
- phagocytosis) justify the description of the 'Chemotaxome' as a new member of 'Omes', where
classication is supported at dierent levels of systems biology.
In this presentation, the 'Chemotaxome' and its organization, will be discussed with respect to the
most signicant levels of the chemotaxome network:
- migration is a general property of prokaryotic (bacteria) and eukaryotic cells (i.e. ciliates, amoebas, sperm, WBCs etc.) though it is uniquely dened for dierent taxa (Taxonome);
- chemotaxis/chemokinesis represents a characteristic type of cell biological responses and covers a wide scale of responses in healthy tissues/individuals (i.e. fertilization, dierentiation of tissues, angiogenesis) as well as in pathological cases (Functiome);
- dedicated groups of signalling molecules (i.e. chemokines, formyl peptides as well as non-professional chemoattractants) are required for chemotaxis, while chemotaxis receptors (i.e. FPR, CCR, CXCR) and their intracellular signalling pathways have unique sensitivity towards to the triggering chemoattractant (Ligandome, Regulome, Interactome, Proteome-Glycome-Lipidome).
Lecturer |
Assoc Prof Laszlo Kohidai Head of Chemotaxis Research Group -- SRI Core Facility Department of Genetics, Cell- & Immunobiology Semmelweis University, Budapest, Hungary |
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Title | Chemotaxome - A new member with complex biological entities in systems biology |
Date / Time | Mon, 24 Feb 2014 / 16:00-17:00 |
Venue | 2nd Floor Seminar Room (#A207) iCeMS Main Building (#70), Kyoto University -> Directions |
Flyer | PDF (324KB) |
Host | Kyoto University Institute for Integrated Cell-Material Sciences (WPI-iCeMS) | Contact | iCeMS Sivaniah Group | sivaniah-g@icems.kyoto-u.ac.jp |