第41回 アイセムスセミナー / CeMI セミナーシリーズ 13: Prof. J. Howard、Prof. H. Oberleithner
CeMI：Center for Meso-Bio Single-Molecule Imaging
Molecular Control of Cellular Size:
Microtubule Length Regulation by the Depolymerase Kinesin-8
(Prof. Jonathon Howard)
Prof. Howard will present his recent discovery of a mechanism by which the cell length is controlled. The motor protein kinesin-8 disassembles longer microtubules faster than shorter ones. The longer the microtubule, the more motors land on it; the motors are so processive that almost all get to the plus end; and at the plus end each motor removes just a single tubulin dimer. Thus the depolymerization rate is proportional to the flux of motor to the end, which is proportional to the number of motors that land on the microtubule, which is proportional to the length of the microtubule. Thus kinesin-8 provides feedback from length back onto the polymerization dynamics, providing a molecular mechanism to control size up to the micron scale (Varga et al. Cell 2009).
Nanomechanics of Vascular Endothelium
(Prof. Hans Oberleithner)
The inner layer of blood vessels is made of endothelial cells which participate in the control of blood pressure and tissue perfusion. Shape, size and stiffness of endothelial cells changes with function. By using atomic force microscopy (AFM), Prof. Oberleithner measured these fundamental parameters in living cells and related them to specific functional states, clearly showing that relating nanomechanics to cellular function allows novel insights into the molecular mechanisms of blood pressure regulation.
| 講演者 演題 |
Prof. Jonathon Howard Prof. Hans Oberleithner |
|---|---|
| 日時 | 2009年12月9日（水）15:00-17:00 |
| 場所 | 京都大学 iCeMSコンプレックス1 本館 2階 セミナールーム (A207) アクセスマップ |
| フライヤー |  PDF (132KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） 京都大学 再生医科学研究所 楠見研究室 科学技術振興機構 ICORP 膜機構プロジェクト |
| 連絡先 | 京大再生研 楠見 明弘 akusumi@frontier.kyoto-u.ac.jp Fax: 075-751-4113 |