第150回 アイセムスセミナー: Zhu-Jun Yao 教授

Annonaceous acetogenins have been attracting worldwide attention as potent inhibitors against proliferation of various tumor cells and environmental neurotoxins for more than 30 years. Mechanism studies mentioned that this large family of plant polyketides might target Complex I of mitochondria during their actions. Our 10-year-long studies on bullatacin, a typical cytotoxic natural annonaceous acetogenin, and corresponding natural product-like mimicking have discovered a number of simplified compounds exhibiting potent antitumor activity and significant action selectivity between human normal and cancerous cells. Furthermore, a representative mimic AA005 has been successfully developed and applied as a molecular tool to explore the unique mechanism of selective anticancer action.

Lecturer	Prof. Zhu-Jun Yao Nanjing University School of Chemistry and Chemical Engineering
Title	Natural Product-like Mimicry of Annonaceous Acetogenins
Date / Time	Fri, 29 Nov 2013 / 11:00-11:40
Venue	CB-217 Lecture Room 3 Institute for Chemical Research Uji Research Bldg (#19), Kyoto University -> Directions
Flyer	PDF (100KB)
Host	Kyoto University Institute for Integrated Cell-Material Sciences (WPI-iCeMS)
Contact	iCeMS Uesugi Lab | uesugi-g@icems.kyoto-u.ac.jp