第158回 アイセムスセミナー: Laszlo Kohidai 准教授

Chemotaxis is one of the most signicant cellular responses in functional cell biology. Integrated cellular, biomaterial and functional complexity of the response system (cell adhesion - chemotaxis - phagocytosis) justify the description of the 'Chemotaxome' as a new member of 'Omes', where classication is supported at dierent levels of systems biology.

In this presentation, the 'Chemotaxome' and its organization, will be discussed with respect to the most signicant levels of the chemotaxome network:

  1. migration is a general property of prokaryotic (bacteria) and eukaryotic cells (i.e. ciliates, amoebas, sperm, WBCs etc.) though it is uniquely dened for dierent taxa (Taxonome);
  2. chemotaxis/chemokinesis represents a characteristic type of cell biological responses and covers a wide scale of responses in healthy tissues/individuals (i.e. fertilization, dierentiation of tissues, angiogenesis) as well as in pathological cases (Functiome);
  3. dedicated groups of signalling molecules (i.e. chemokines, formyl peptides as well as non-professional chemoattractants) are required for chemotaxis, while chemotaxis receptors (i.e. FPR, CCR, CXCR) and their intracellular signalling pathways have unique sensitivity towards to the triggering chemoattractant (Ligandome, Regulome, Interactome, Proteome-Glycome-Lipidome).
The genetic determination of these three interacting components mentioned above are coded in the DNA of the cell (e.g. IL-8 - 4q13-q21) (Genome); while complex relations of molecular genetic backgrounds and phylogenetic approaches (i.e. amino acids of prebiotic soup; chemotactic selection) belong to the molecular aspects of evolution (Phylogenome).

講演者
Laszlo Kohidai 准教授
Head of Chemotaxis Research Group -- SRI Core Facility
Department of Genetics, Cell- & Immunobiology
Semmelweis University, Budapest, Hungary
演題 Chemotaxome - A new member with complex biological entities in systems biology
日時 2014年2月24日（月）16:00-17:00
場所 京都大学 iCeMS 本館（#70）2階 セミナールーム (A207)
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フライヤー PDF FilePDF (324KB)
主催 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス）
連絡先 Sivaniah グループ | sivaniah-g@icems.kyoto-u.ac.jp