第197回 アイセムスセミナー: 高木 雄一郎 博士
Mediator is an essential regulator of eukaryotic transcription. It is a gigantic multi-protein complex composed of 21 subunits with a molecular mass exceeding 1 Mega daltons.
The structural complexity of Mediator has been a huge roadblock for structure-function studies on Mediator. We have developed a new technology, which enables us to reconstitute the 21-subunit full Mediator complex, opening new avenues to understand how Mediator functions during transcription, and why mutations disrupt its function, leading toward determining the transcription activation mechanisms by Mediator.
| 講演者 |  Department of Biochemistry and Molecular Biology インディアナ大学 医学研究科 |
|---|---|
| 演題 | Synthetic biology approach to uncover structure and function of the Mediator of transcription regulation |
| 日時 | 2015年12月28日（月）15:30-16:30 |
| 場所 | 京都大学 iCeMS 本館（#77）2階 セミナールーム (A207) -> アクセスマップ |
| フライヤー |  PDF (145KB) |
| 主催 | 京都大学 物質－細胞統合システム拠点（iCeMS＝アイセムス） |
| 連絡先 | 原田グループ | harada-g@icems.kyoto-u.ac.jp |