207th iCeMS Seminar: Dr Isao Kii
Autophosphorylation of amino-acid residues is part of folding process of various kinases. Conventional chemical screening has missed inhibitors that selectively interfere with the folding process. Here we report a folding intermediate-selective inhibitor of DYRK1A. Our study demonstrates that folding intermediates of kinases can be targeted by small molecules, and paves the way for developing novel types of inhibitors.
- Lecturer
-
Dr Isao Kii
Pathophysiological and Health Science Team, Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies
- Title
- Selective inhibition of the kinase DYRK1A by targeting its folding process
- Date / Time
- Wed, Jul 6, 2016 / 16:00-17:00
- Venue
-
2nd floor Seminar Room (#A207), iCeMS Main Building (#77), Kyoto University
Directions
- Flyer
- Host
- Kyoto University Institute for Integrated Cell-Material Sciences (iCeMS)
- Contact
- iCeMS Wang Lab | ohtan-g (at) icems.kyoto-u.ac.jp
