[Dec 3] Furukawa Lab Seminar: Prof Hitoshi Kasai

Furukawa Labs is to hold a seminar. All researchers are welcomed to attend.

Important notice:
This seminar will be held by a hybrid system (in-person at the iCeMS main building and online via zoom).
In both cases, please register via the google form (through QR code in the flyer below).
The number of available seats in the in-person lecture is limited due to the capacity of the room.

Prof Hitoshi Kasai
Tohoku University
Institute of Multidisciplinary
Research for Advanced Materials (IMRAM)

Nano Drug Delivery Based on New Strategy
In this presentation, we propose a new concept, termed "pure nano-drugs" (PNDs), which are comprised of drug ingredient and are delivered into cells in a carrier-free state without using polymer. As the model of PNDs, the nanoparticles of SN-38 cholesterol succinate which is the derivatives of SN-38 having the high anticancer activity were fabricated with less than 100 nm in size by the reprecipitation method[1] developed at our laboratory[2]. Aqueous dispersion of the nanoparticles has been shown to exhibit an extremely effective anti cancer activity not only in vitro experiment but also in vivo experiment, when compared to irinotecan, a prodrug of SN-38 and a widely used watersoluble anticancer monomer[3].

References
[1] H. Kasai et al. Jpn. J. Appl. Phys., 31, L1132−L1134. (1992).
[2] H. Kasai et al. Angew. Chem. Int. Ed., 51, 10315 –10318 (2012).
[3] Y. Koseki et al. Bull. Chem. Soc. Jpn., 92, 1305, (2019).