iCeMS見学グループセミナー：Andrea Ravasio 博士

　このたび、高等研究院物質－細胞統合システム拠点 (iCeMS) 見学グループでは、
セミナーを以下の通り開催いたします。
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Andrea Ravasio 博士
Assistant professor, Institute for Biological and Medical Engineering, Pontificia Universidad Catolica de Chile

Heterogeneity in cancer and stem cell populations : from biomechanical cues to clinical applications
Population heterogeneity is inbuilt strategy of living organisms to ensure efficient adaptation to the everchanging environment. Nevertheless, tissues in higher organisms are composed by extraordinarily homogenous cells to execute a coherent function. Cells have several layers of control in place to suppress their spontaneous tendency to diverge from the original cell. However, such controlling mechanisms seem to be strongly dependent on correct chemical and mechanical sensing of the environment. Therefore, we observe that cancer cells, who live in a very dynamic environment, evolve into heterogenous populations and through Darwinian selection manage to survive chemotherapy and cause recurrence of the disease. Similarly, freshly isolated stem cells lose their ability to remain as a homogeneous population as soon as they are cultured with unspecific growth factors, on plastic surfaces and inside the incubator. This poses serious challenges in developing cell therapies of high efficacy. In this talk, I will discuss our recent efforts to develop engineering strategies to detect and control population heterogeneity in cancer and stem cell populations.