iCeMS鈴木グループセミナー：Mark Isalan 教授

このたび、高等研究院物質－細胞統合システム拠点 (iCeMS) 鈴木グループでは、セミナーを以下の通り開催いたします。

事前申し込みは不要ですので、皆様のご参加をお待ちしております。

Mark Isalan 教授
Synthetic Biology, Life Sciences, Imperial College London

Synthetic biology: from gene circuits to gene therapy
Recent advances in synthetic biology, directed evolution and genetic circuit engineering could lead to new practical applications. We are developing methods to engineer new proteins and transcription factors for bottom-up engineering of small genetic circuits. Furthermore, we are exploring ways to “rewire” large cellular networks, to access phenotype space conveniently. Finally, we have developed artificial zinc finger (ZF) transcription factor repressors to switch off the mutant huntingtin gene in Huntington’s disease (HD). By injecting AAV viruses expressing ZF, we were able to switch off mutant huntingtin by 80% in whole mouse brains, with effects lasting 6 months after a single injection. Thus, synthetic biology holds great promise for both biotechnology and medicine.