【12/3開催】古川グループセミナー：Hitoshi Kasai 教授

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Hitoshi Kasai 教授
Tohoku University
Institute of Multidisciplinary
Research for Advanced Materials (IMRAM)

Nano Drug Delivery Based on New Strategy
In this presentation, we propose a new concept, termed "pure nano-drugs" (PNDs), which are comprised of drug ingredient and are delivered into cells in a carrier-free state without using polymer. As the model of PNDs, the nanoparticles of SN-38 cholesterol succinate which is the derivatives of SN-38 having the high anticancer activity were fabricated with less than 100 nm in size by the reprecipitation method[1] developed at our laboratory[2]. Aqueous dispersion of the nanoparticles has been shown to exhibit an extremely effective anti cancer activity not only in vitro experiment but also in vivo experiment, when compared to irinotecan, a prodrug of SN-38 and a widely used watersoluble anticancer monomer[3].

References
[1] H. Kasai et al. Jpn. J. Appl. Phys., 31, L1132−L1134. (1992).
[2] H. Kasai et al. Angew. Chem. Int. Ed., 51, 10315 –10318 (2012).
[3] Y. Koseki et al. Bull. Chem. Soc. Jpn., 92, 1305, (2019).