
Junior Associate Professor / PI
Ganesh Pandian Namasivayam Ganesh Pandian Namasivayam

Research Interest
Bio-inspired Therapeutics, Epigenetics
My research goal is to create “Smart Genetic Switches” that precisely ON and OFF the genetic and epigenetic factor(s) of interest. Harnessing the genetic information acquired by high-throughput technologies, we can gain artificial control over desired cell-type-specific genes using DNA-based epigenetic switches and achieve targeted reprogramming and differentiation. Advancing our synthetic strategy to construct tailor-made switches for therapeutically important genes associated with diseases like diabetes, autism and cancer could open new vistas of clinical opportunities.
What I like about my science
I enjoy my science because it allows me to keep a sense of wonder and live my childhood passion for exploring and decoding mysteries like the cell’s secret codes. Tunability of our chemical tools and the necessity to integrate diverse disciplines rekindles my creative capacity.
Researcher Q & A
Where are you from?
Tirunelveli, TamilNadu (A state in India where people speak world’s oldest language).
Why did you become a researcher?
I was amazed to see how a genetic material could be orchestrated to regenerate dinosaurs in the movie “Jurassic Park” and felt inspired to pursue a career in research.
What is your favorite experiment, theory, device, reagent, lab equipment? Why do you like it?
My favorite is `Game theory` because of its versatile application in wide-range of phenomenon including genetic and epigenetic codes. Since the status of all life systems depends upon the decisions they make at right place and time, this theory on strategic decision-making excites me and assists in gaining insights into disease and regulatory processes.
What is your hobby?
I refresh myself by playing chess. Even with restricted moves, this game (also an art) offers infinite possibilities and lets my imagination soar. Also, it promotes my decision-making skills.


Members
Papers
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Targeted Epigenetic Induction of Mitochondrial Biogenesis Enhances Antitumor Immunity in Mouse Model
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Targeted Elimination of Mutated Mitochondrial DNA by a Multi-functional Conjugate Capable of Sequence-specific Adenine Alkylation
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CGHF: A Computational Decision Support System for Glioma Classification Using Hybrid Radiomics- and Stationary Wavelet-Based Features
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A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus
Media
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がん免疫治療、効果高める手法。
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「ミトコンドリア活性化」京大が中分子化合物を開発 マウス生存率向上
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オプジーボの効果高める化合物開発 ミトコンドリア活性化、京都大グループ
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がん免疫療法効果増に期待 京大グループ 化合物開発
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がん免疫治療薬、有効性が向上、京都大教授ら、ミトコンドリア活性化で。
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<めざまし8>京大発表 ミトコンドリアでがん免疫治療薬の効果UP
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京大、化合物で変異ミトコンドリアDNA減少 遺伝子治療に応用
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<やさしいニュース>京都大学 難病のミトコンドリア病治療に可能性
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Artificial intelligence enhances brain tumour diagnosis
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கொரோனா தடுப்பு மருந்து கண்டுபிடிப்பதில் உள்ள சிக்கல் என்ன? – மருத்துவ விஞ்ஞானி கணேஷ் பாண்டியன்
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ஓரிரு வாரங்களில் கொரோனா தடுப்பு மருந்து கண்டுபிடிக்கப்பட வாய்ப்பு: ஜப்பான் மருத்துவ விஞ்ஞானி
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京大、特定の場所の遺伝子を活性化できる新しい分子を開発-遺伝子活性異常が引き起こす病気の研究に応用
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京大、合成分子を用いてヒトiPS細胞などの幹細胞を心筋細胞へと分化させる新たな方法を開発
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京大、ミトコンドリア内のDNAに結合させることで神経・筋肉疾患に関わる遺伝子を抑制することに成功